9/26/2023 0 Comments Plexiform layersInstead the peripapillary retinal nerve fiber layer (pRNFL) parameter has been more widely explored. Although the reliability and repeatability have been proven to be satisfying when examining children with Cirrus SD-OCT the GC-IPL parameter has not been extensively investigated for younger age groups and there is no normative database. The macular ganglion cell + inner plexiform layer (GC-IPL) has proven to be of interest in detection and follow-up of for instance in glaucoma and other optic nerve diseases: optic pathway glioma, compressive optic neuropathies and hereditary neuropathies. Moreover, advances in segmentation algorithms have permitted measurement of individual retinal layers in the macular region. The newer, spectral domain technology (SD-OCT) offers three-dimensional, high-speed retinal imaging and thereby enables high resolution imaging less sensitive to eye movements than time domain technology-based OCT. Since OCT came into clinical use it has undergone several improvements. Optical coherence tomography (OCT) is a non-invasive and objective imaging technique that provides cross-sectional images of the retinal layers and the optic nerve. It could therefore be assumed that larger variations are sensitive markers of focal GC-IPL thinning due to damage to the primary visual pathways in children. The GC-IPL thickness variations within eyes and within eye pairs are generally small. This study provides normative GC-IPL thickness values for healthy 6.5 year- old Swedish children. The average GC-IPL thickness was weakly positively correlated with SE (spherical equivalent combined sphere and ½ cylinder) ( p = 0.031, Spearman’s ρ 0.23). There was a moderate correlation in the difference between the nasal combined and the temporal combined sectors within eye pairs ( p < 0.0001, Spearman’s ρ 0.58). The difference between the thickest and thinnest sector within eye was 6.4 μm (± 2.2 5th and 95th percentiles were 3.0 and 10.0 μm). The difference between average GC-IPL thickness and minimum GC-IPL thickness was 2.3 μm (± 1.9 5th and 95th percentiles were 0.0 and 6.0 μm). The difference in thickness between nasal and temporal sectors and between superior and inferior hemisphere sectors were less than 2 μm. The mean minimum GC-IPL thickness was 83.6 μm (± 4.9 5th and 95th percentiles were 75.4 and 92.3 μm). The mean average GC-IPL thickness was 85.9 μm (± 5.3 5th and 95th percentiles were 76.0 and 94.6 μm). ResultsĮighty-five children completed the OCT examination and 155 out of 181 scans (86%) were analyzed. Visual acuity, refraction and general cognition were assessed and correlated to GC-IPL outcome. Intra-individual GC-IPL thickness between eye pairs was analyzed. Single sectors, combined sectors defined as superior and inferior hemispheres and temporal and nasal sectors were evaluated. Main outcome measures were average and minimum values of GC-IPL thickness of the device’s predefined macular sectors. MethodsĪ total of 181 eyes of 92 healthy children (39 girls, 53 boys) aged 6.5 and serving as a term-born control group in the Extremely Preterm Infants in Sweden Study (EXPRESS), were examined with Cirrus HD-OCT. The purpose was to study the macular ganglion cell- inner plexiform layer (GC-IPL) thickness in healthy 6.5 year- old Swedish children using Optical Coherence Tomography (OCT) and to study topography symmetry within eyes and between eye pairs.
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